https://spakowiczlab.github.io/updates/Recent content in Updates on Spakowicz LabHugoen-usSun, 04 Oct 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/farewell-rebecca/Sun, 04 Oct 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/farewell-rebecca/<p>We had a potluck picnic at the Tall Pines area of Walnut Woods Metro Park. It was great to see everyone and to wish Rebecca well on the next step of her journey!</p>https://spakowiczlab.github.io/updates/grant-fa068b48af6b/Thu, 01 Oct 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-fa068b48af6b/<p><strong>2026 Spielman Fund Bridge-to-Impact Clinical Trial Award (AWD-122995; Non-OSP; Co-PI: Spakowicz)</strong> begins today.</p> <p>Ohio State University Internal Award</p> <p>The Vaginal Microbiome as a Biomarker of Vaginal Health in Women with Breast Cancer</p>https://spakowiczlab.github.io/updates/preprint-75f1c73d9f73/Tue, 25 Aug 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-75f1c73d9f73/<p>Our preprint <strong>Pre-treatment T-cell Transcriptional Signatures Predict Immunotherapy Outcomes in Melanoma</strong> was posted today.</p> <p><a href="https://doi.org/10.21203/rs.3.rs-10629841/v1">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/preprint-283641c701c9/Tue, 28 Jul 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-283641c701c9/<p>Our preprint <strong>Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5</strong> was posted today.</p> <p><a href="https://doi.org/10.64898/2026.07.27.741033">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-7e47813a5086/Wed, 01 Jul 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-7e47813a5086/<p><strong>Harold and Barbara Rosenbaum Family Foundation Cervical Cancer Diversity in Prevention &amp; Clinical Research Grant (PI: O’Connor)</strong> begins today.</p> <p>Foundation for Women’s Cancer</p> <p>Probiotic and Dietary Fiber Supplementation to Potentiate Immunotherapy Response in Cervical Cancer</p>https://spakowiczlab.github.io/updates/grant-62b06fc85f97/Wed, 01 Jul 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-62b06fc85f97/<p><strong>Ovarian Cancer Clinical Trial Academy – Early-Career Investigator Award (PI: Chambers)</strong> begins today.</p> <p>Department of War Ovarian Cancer Research Program</p> <p>Modulating the Microbiome to Transform Platinum-Based Care in Ovarian Cancer</p>https://spakowiczlab.github.io/updates/grant-c30a13af4d45/Wed, 01 Jul 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-c30a13af4d45/<p><strong>R21CA2973842 (PI: Spakowicz, Bradley, Zhu)</strong> begins today.</p> <p>National Cancer Institute</p> <p>Lachnospiraceae characterization to affect diet-mediated improvement of cancer treatment outcomes</p> <p>Goal: To determine how Lachnospiraceae alters cancer immunotherapy outcomes and to identify potential biotherapeutic targets. Specifically, the project aims to identify and isolate Lachno genes associated with tumor reduction and to test the causal relationship between these isolates, their metabolites, and ICB response using preclinical mouse models.</p>https://spakowiczlab.github.io/updates/paper-42364424/Sat, 27 Jun 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-42364424/<p><strong>PRO-PLATINUM: A randomized, double-blind, placebo controlled study to investigate the efficacy of a probiotic intervention on the gut and vaginal microbiome of ovarian cancer patients undergoing treatment with platinum chemotherapy</strong> was published today in <em>Gynecologic oncology</em>.</p>https://spakowiczlab.github.io/updates/paper-42302785/Tue, 16 Jun 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-42302785/<p><strong>Power and sample-size estimation in human microbiome research</strong> was published today in <em>Med (New York, N.Y.)</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/42302785/">Read the paper</a> · <a href="https://doi.org/10.1016/j.medj.2026.101174">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-42327585/Wed, 10 Jun 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-42327585/<p><strong>Association between obesity, sex, medical comorbidities, and survival in cancer patients treated with immune checkpoint inhibitors</strong> was published today in <em>Journal of Cancer</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/42327585/">Read the paper</a> · <a href="https://doi.org/10.7150/jca.130032">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-76792e955a9a/Tue, 02 Jun 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-76792e955a9a/<p>Our preprint <strong>The Oncology Research Information Exchange Network (ORIEN) – Building a real-world collaborative, patient-driven infrastructure for discovery research and precision oncology</strong> was posted today.</p> <p><a href="https://doi.org/10.21203/rs.3.rs-7077810/v1">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-42077003/Mon, 04 May 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-42077003/<p><strong>How the Ketogenic Diet Shapes the Microbiome to Influence Cancer Immunotherapy Outcomes: An Exploration of Clinical Trials and Their Results</strong> was published today in <em>Nutrition and cancer</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/42077003/">Read the paper</a> · <a href="https://doi.org/10.1080/01635581.2026.2658807">Publisher</a>.</p>https://spakowiczlab.github.io/updates/paper-41991647/Thu, 16 Apr 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-41991647/<p><strong>Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites</strong> was published today in <em>Scientific reports</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41991647/">Read the paper</a> · <a href="https://doi.org/10.1038/s41598-026-48719-5">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-book/Mon, 30 Mar 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-book/<p><strong>The Role of the Microbiome in Modulating Human Health</strong> was published today in <em>Soil and Human Health</em>.</p> <p><a href="https://doi.org/10.1201/9781003469742-6">Read the chapter</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41905324/Sat, 28 Mar 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-41905324/<p><strong>Implementing non-invasive biospecimen collection in gynecologic oncology: Insights from a prospective gut microbiome feasibility study</strong> was published today in <em>Gynecologic oncology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41905324/">Read the paper</a> · <a href="https://doi.org/10.1016/j.ygyno.2026.03.008">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41801404/Mon, 09 Mar 2026 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-41801404/<p><strong>Impact of proton pump inhibitors on immunotherapy is modulated by prior chemotherapy and linked to gut microbiome-immune cell signatures</strong> was published today in <em>Cancer immunology, immunotherapy : CII</em>.</p>https://spakowiczlab.github.io/updates/preprint-ffdd147ec80e/Fri, 30 Jan 2026 00:00:00 -0500https://spakowiczlab.github.io/updates/preprint-ffdd147ec80e/<p>Our preprint <strong>Intrinsic tumor factors and extrinsic environmental and social exposures contribute to endometrial cancer recurrence patterns</strong> was posted today.</p> <p><a href="https://doi.org/10.21203/rs.3.rs-8682460/v1">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-41683263/Thu, 29 Jan 2026 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41683263/<p><strong>Gut Microbiota and Nutritional Profiles of Colon Cancer Patients Undergoing Chemotherapy: A Longitudinal Pilot Study</strong> was published today in <em>Nutrients</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41683263/">Read the paper</a> · <a href="https://doi.org/10.3390/nu18030438">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41526666/Tue, 13 Jan 2026 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41526666/<p><strong>ShinyEvents: harmonizing longitudinal data for real-world survival estimation</strong> was published today in <em>NPJ precision oncology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41526666/">Read the paper</a> · <a href="https://doi.org/10.1038/s41698-025-01212-0">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41500775/Wed, 07 Jan 2026 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41500775/<p><strong>Tumor-infiltrating microbes and therapy response: a new frontier in triple-negative breast cancer precision oncology</strong> was published today in <em>Journal for immunotherapy of cancer</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41500775/">Read the paper</a> · <a href="https://doi.org/10.1136/jitc-2025-013314">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41482525/Fri, 02 Jan 2026 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41482525/<p><strong>Tumor bacterial burden dictates immunotherapy fate in head and neck cancer</strong> was published today in <em>Nature cancer</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41482525/">Read the paper</a> · <a href="https://doi.org/10.1038/s43018-025-01074-2">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-28641a57fa20/Mon, 22 Dec 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/preprint-28641a57fa20/<p>Our preprint <strong>Gut Microbiome and Nutritional Profiles of Colon Cancer Patients Undergoing Chemotherapy: A Longitudinal Pilot Study</strong> was posted today.</p> <p><a href="https://doi.org/10.20944/preprints202512.1995.v1">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-41418290/Fri, 19 Dec 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41418290/<p><strong>Effects of Walnuts on Postprandial Cognitive Function in Adults With Subjective Cognitive Impairment: Protocol for a Randomized Crossover Trial</strong> was published today in <em>JMIR research protocols</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41418290/">Read the paper</a> · <a href="https://doi.org/10.2196/82032">Publisher</a>.</p>https://spakowiczlab.github.io/updates/paper-41335275/Wed, 03 Dec 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41335275/<p><strong>Phase 1 dose escalation trial of the selective adenosine A2B antagonist PBF-1129 in patients with metastatic non-small cell lung cancer</strong> was published today in <em>Investigational new drugs</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41335275/">Read the paper</a> · <a href="https://doi.org/10.1007/s10637-025-01591-y">Publisher</a>.</p>https://spakowiczlab.github.io/updates/grant-d210315e66e7/Mon, 01 Dec 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-d210315e66e7/<p><strong>Stephanie Spielman Research Funds (PI: Spakowicz, Jhawar, Myers)</strong> begins today.</p> <p>The Ohio State University Comprehensive Cancer Center</p> <p>Spatial association of tumor microbes and the tumor microenvironment in breast cancer subtypes</p>https://spakowiczlab.github.io/updates/paper-41286005/Mon, 24 Nov 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41286005/<p><strong>Primary tumor microbiomes predict distant metastasis of colorectal cancer</strong> was published today in <em>NPJ precision oncology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41286005/">Read the paper</a> · <a href="https://doi.org/10.1038/s41698-025-01188-x">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41134679/Wed, 12 Nov 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-41134679/<p><strong>Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer</strong> was published today in <em>Cancer research communications</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41134679/">Read the paper</a> · <a href="https://doi.org/10.1158/2767-9764.CRC-25-0177">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41070402/Fri, 10 Oct 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-41070402/<p><strong>Early Changes in Lymphocyte/Monocyte Ratio on Treatment as a Prognostic Marker to Predict Overall Survival in Patients with Advanced Cancer Treated with Immune Checkpoint Inhibitors</strong> was published today in <em>Cancer investigation</em>.</p>https://spakowiczlab.github.io/updates/paper-41063459/Thu, 09 Oct 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-41063459/<p><strong>Colon cancer in Appalachian Kentucky: Unique genetic, microbiome and obesity findings in a cohort comparison</strong> was published today in <em>HGG advances</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41063459/">Read the paper</a> · <a href="https://doi.org/10.1016/j.xhgg.2025.100527">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-41072704/Wed, 08 Oct 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-41072704/<p><strong>Assessment of probiotic and prebiotic use in gynecologic cancer patients: a systematic review</strong> was published today in <em>American journal of obstetrics and gynecology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/41072704/">Read the paper</a> · <a href="https://doi.org/10.1016/j.ajog.2025.09.042">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-d23e2b4a7ddd/Sun, 21 Sep 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-d23e2b4a7ddd/<p>Our preprint <strong>Candida albicans infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2025.09.19.677366">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-40954302/Mon, 15 Sep 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-40954302/<p><strong>The new microbiome on the block: challenges and opportunities of using human tumor sequencing data to study microbes</strong> was published today in <em>Nature methods</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/40954302/">Read the paper</a> · <a href="https://doi.org/10.1038/s41592-025-02807-y">Publisher</a>.</p>https://spakowiczlab.github.io/updates/preprint-c200e87270a9/Fri, 08 Aug 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-c200e87270a9/<p>Our preprint <strong>Effects of Walnuts on Postprandial Cognitive Function in Adults With Subjective Cognitive Impairment: Protocol for a Randomized Crossover Trial</strong> was posted today.</p> <p><a href="https://doi.org/10.2196/preprints.82032">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/preprint-3d09e6e0e65e/Wed, 06 Aug 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-3d09e6e0e65e/<p>Our preprint <strong>ShinyEvents: harmonizing longitudinal data for real world survival estimation</strong> was posted today.</p> <p><a href="https://doi.org/10.21203/rs.3.rs-7231850/v1">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-40719750/Mon, 28 Jul 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-40719750/<p><strong>Early Acute Kidney Injury and Its Association With Survival in Patients With Metastatic Non-Small-Cell Lung Cancer Treated With Front-Line Immunotherapy-Based Therapies</strong> was published today in <em>Cancer medicine</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/40719750/">Read the paper</a> · <a href="https://doi.org/10.1002/cam4.71058">Publisher</a>.</p>https://spakowiczlab.github.io/updates/paper-40896728/Sat, 21 Jun 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-40896728/<p><strong>Exploratory evaluation of immunotherapy response and medication use in endometrial and cervical carcinoma</strong> was published today in <em>Gynecologic oncology reports</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/40896728/">Read the paper</a> · <a href="https://doi.org/10.1016/j.gore.2025.101782">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-4913896121be/Thu, 05 Jun 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-4913896121be/<p>Our preprint <strong>Primary tumor microbiomes predict distant metastasis of colorectal cancer</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2025.06.02.654060">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-5863ffb6f720/Sun, 01 Jun 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-5863ffb6f720/<p><strong>Wendy Brewster, MD, PhD Accelerator (PI: Chambers)</strong> begins today.</p> <p>Foundation for Women’s Cancers</p> <p>“PROPLATINUM Study: Leveraging microbes to improve women’s cancer outcomes”</p> <p>Goal: To assess whether a probiotic supplement will improve treatment outcomes in the context of platinum-based therapies for gynecologic cancers</p>https://spakowiczlab.github.io/updates/paper-40450912/Sat, 31 May 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-40450912/<p><strong>The impact of antibiotics, proton pump inhibitors, H2-receptor antagonists, and steroids on survival in ovarian cancer patients receiving PARP inhibitor therapy</strong> was published today in <em>Gynecologic oncology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/40450912/">Read the paper</a> · <a href="https://doi.org/10.1016/j.ygyno.2025.05.012">Publisher</a>.</p>https://spakowiczlab.github.io/updates/preprint-e0f84ac76ba4/Thu, 29 May 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-e0f84ac76ba4/<p>Our preprint <strong>mt.surv: Multi-Threshold Survival Analysis for Associating Continuous Predictor Variables with Time-to-Event Outcomes</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2025.05.29.656703">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-5d1c4c495f7d/Thu, 01 May 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-5d1c4c495f7d/<p><strong>Radiation Oncology Departmental Seed Grant (PIs: Quick and Pitter)</strong> begins today.</p> <p>Vaginal DHEA for Women with Gynecologic and Gastrointestinal Cancer After Radiation</p> <p>Goal: To evaluate the effect of vaginal dehydroepiandosterone (DHEA) alters the vaginal microbiome in a way that affects treatment outcomes and toxicity following pelvic radiation.</p>https://spakowiczlab.github.io/updates/paper-40296253/Mon, 28 Apr 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-40296253/<p><strong>Role of insulinemic and inflammatory dietary patterns on gut microbial composition and circulating biomarkers of metabolic health among older American men</strong> was published today in <em>Gut microbes</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/40296253/">Read the paper</a> · <a href="https://doi.org/10.1080/19490976.2025.2497400">Publisher</a>.</p>https://spakowiczlab.github.io/updates/preprint-90122801eecb/Wed, 02 Apr 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-90122801eecb/<p>Our preprint <strong>Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2025.03.28.645992">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-39868697/Mon, 17 Mar 2025 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-39868697/<p><strong>Survival Disparity and the Unique Genomic and Microbiome Profiles of Colon Cancer in Appalachian Kentucky</strong> was published today in <em>Journal of the American College of Surgeons</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39868697/">Read the paper</a> · <a href="https://doi.org/10.1097/XCS.0000000000001299">Publisher</a>.</p>https://spakowiczlab.github.io/updates/preprint-d2d0e6dd8c09/Fri, 31 Jan 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/preprint-d2d0e6dd8c09/<p>Our preprint <strong>The Association of the Microbiome with Melanoma Tumor Response to Immune Checkpoint Inhibitor Treatment and Immune-Related Adverse Events (NCT05102773)</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2025.01.30.25321413">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-39856008/Fri, 24 Jan 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-39856008/<p><strong>The Role of the Microbiome in Cancer Therapies: Current Evidence and Future Directions</strong> was published today in <em>Hematology/oncology clinics of North America</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39856008/">Read the paper</a> · <a href="https://doi.org/10.1016/j.hoc.2024.12.005">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-fd54083532a6/Fri, 17 Jan 2025 00:00:00 -0500https://spakowiczlab.github.io/updates/preprint-fd54083532a6/<p>Our preprint <strong>Berry Supplement-Modified Human Microbiome Improves Immunotherapy Response in Mouse Models</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2025.01.16.25320666">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-39701328/Tue, 17 Dec 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-39701328/<p><strong>Dynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program</strong> was published today in <em>Brain, behavior, and immunity</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39701328/">Read the paper</a> · <a href="https://doi.org/10.1016/j.bbi.2024.12.027">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/grant-a7dab1446e37/Fri, 13 Dec 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-a7dab1446e37/<p><strong>FastTrack Program Grant (PI: Presley)</strong> begins today.</p> <p>Bristol Myers Squibb</p> <p>“LiveWellLung: A Prehabilitation Education and Intervention Program Prior to Lung Cancer Surgery”</p> <p>Goal: To reduce the incidence of post-surgical complications through pre-treatment lifestyle-based modifications including those expected to operate via the microbiome.</p>https://spakowiczlab.github.io/updates/paper-39703541/Thu, 05 Dec 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-39703541/<p><strong>Pro-inflammatory and hyperinsulinaemic dietary patterns are associated with specific gut microbiome profiles: a TwinsUK cohort study</strong> was published today in <em>Gut microbiome (Cambridge, England)</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39703541/">Read the paper</a> · <a href="https://doi.org/10.1017/gmb.2024.14">Publisher</a>.</p>https://spakowiczlab.github.io/updates/paper-39682743/Tue, 03 Dec 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-39682743/<p><strong>Differential Infiltration of Key Immune T-Cell Populations Across Malignancies Varying by Immunogenic Potential and the Likelihood of Response to Immunotherapy</strong> was published today in <em>Cells</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39682743/">Read the paper</a> · <a href="https://doi.org/10.3390/cells13231993">Publisher</a>.</p>https://spakowiczlab.github.io/updates/preprint-2bbabb047322/Sat, 02 Nov 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-2bbabb047322/<p>Our preprint <strong>Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2024.10.29.620864">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-f14820061887/Fri, 01 Nov 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-f14820061887/<p><strong>CCC Transitional Therapeutics FY25 seed award (PIs: Vershraegen, Spakowicz, Presley, and Burd)</strong> begins today.</p> <p>The Ohio State University Comprehensive Cancer Center</p> <p>Investigation of Age-Specific Effects of Indole Supplementation on Immune Function and irAE Development</p>https://spakowiczlab.github.io/updates/grant-8c6b0c5ef1bd/Fri, 01 Nov 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-8c6b0c5ef1bd/<p><strong>CFAES-CCC-FFH Joint Seed Grant (PIs: Belury, Spakowicz, Pyter)</strong> begins today.</p> <p>The Ohio State University</p> <p>“Prevention of Cancer Cachexia by Dietary Naringenin: Impact on the Gut-Brain Axis”</p> <p>Goal: To understand how a naringenin dietary supplement affects cancer treatment outcomes in model systems.</p>https://spakowiczlab.github.io/updates/grant-0be3146fb147/Tue, 01 Oct 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-0be3146fb147/<p><strong>2024 Breast Cancer Translational Research Program Team Science Pilot Grant (PIs: Spakowicz, Jhawar)</strong> begins today.</p> <p>The Ohio State University Comprehensive Cancer Center</p> <p>&ldquo;Spatial Association of Tumor Microbes and the Tumor Microenvironment in Breast Cancer Subtypes&rdquo;</p>https://spakowiczlab.github.io/updates/paper-39225619/Tue, 03 Sep 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-39225619/<p><strong>An Explainable Graph Neural Framework to Identify Cancer-Associated Intratumoral Microbial Communities</strong> was published today in <em>Advanced science (Weinheim, Baden-Wurttemberg, Germany)</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39225619/">Read the paper</a> · <a href="https://doi.org/10.1002/advs.202403393">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-39174449/Thu, 22 Aug 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-39174449/<p><strong>Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer</strong> was published today in <em>Journal of geriatric oncology</em>.</p>https://spakowiczlab.github.io/updates/paper-39146792/Wed, 14 Aug 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-39146792/<p><strong>From poo to promise: Fecal microbiota transplants support immunotherapy re-sensitization in solid tumors</strong> was published today in <em>Cell host &amp; microbe</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39146792/">Read the paper</a> · <a href="https://doi.org/10.1016/j.chom.2024.07.015">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-39015091/Thu, 08 Aug 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-39015091/<p><strong>The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors</strong> was published today in <em>Cancer research communications</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39015091/">Read the paper</a> · <a href="https://doi.org/10.1158/2767-9764.CRC-23-0170">Publisher</a>.</p>https://spakowiczlab.github.io/updates/paper-39061235/Sat, 20 Jul 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-39061235/<p><strong>Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis</strong> was published today in <em>Cancers</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39061235/">Read the paper</a> · <a href="https://doi.org/10.3390/cancers16142597">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-38904265/Wed, 10 Jul 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-38904265/<p><strong>The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer</strong> was published today in <em>Cancer research communications</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38904265/">Read the paper</a> · <a href="https://doi.org/10.1158/2767-9764.CRC-23-0367">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/grant-0f269bac9ed6/Mon, 01 Jul 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-0f269bac9ed6/<p><strong>R21CA294050 (PI: Tabung)</strong> begins today.</p> <p>National Cancer Institute</p> <p>Role of the inflammatory dietary pattern in gut and colon tissue microbiomes and impact on survival outcomes among colorectal cancer patients</p>https://spakowiczlab.github.io/updates/paper-38937454/Thu, 27 Jun 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-38937454/<p><strong>Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils</strong> was published today in <em>Nature communications</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38937454/">Read the paper</a> · <a href="https://doi.org/10.1038/s41467-024-48935-5">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-64848fc15b53/Thu, 27 Jun 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-64848fc15b53/<p>Our preprint <strong>Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2024.06.26.600881">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-38911592/Fri, 07 Jun 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-38911592/<p><strong>The FITNESS study: longitudinal geriatric assessment, treatment toxicity, and biospecimen collection to assess functional disability among older adults with lung cancer</strong> was published today in <em>Frontiers in aging</em>.</p>https://spakowiczlab.github.io/updates/preprint-2a21bdf668a0/Mon, 13 May 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-2a21bdf668a0/<p>Our preprint <strong>Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis</strong> was posted today.</p> <p><a href="https://doi.org/10.20944/preprints202405.0890.v1">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-38722731/Thu, 09 May 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-38722731/<p><strong>Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival</strong> was published today in <em>Cancer biology &amp; therapy</em>.</p>https://spakowiczlab.github.io/updates/paper-38662438/Thu, 25 Apr 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-38662438/<p><strong>Bridging the Gap from Bench to Bedside: A Call for In Vivo Preclinical Models to Advance Endometrial Cancer and Cervical Cancer Immuno-oncology Research</strong> was published today in <em>Clinical cancer research : an official journal of the American Association for Cancer Research</em>.</p>https://spakowiczlab.github.io/updates/grant-69a8093a066f/Mon, 01 Apr 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-69a8093a066f/<p><strong>Chief of Science Seedling (PIs: Spakowicz, Bradley, Zhu)</strong> begins today.</p> <p>Air Force Research Lab</p> <p>Next-Generation Culturomics: Cultivation of uncultured gut microbes to optimize warfighter health and performance</p> <p>Goal: To establish methods for cultivating microbes from complex communities for use in experiments to establish causality and as future therapeutics.</p>https://spakowiczlab.github.io/updates/paper-38479397/Tue, 12 Mar 2024 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-38479397/<p><strong>Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease</strong> was published today in <em>Cell host &amp; microbe</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38479397/">Read the paper</a> · <a href="https://doi.org/10.1016/j.chom.2024.02.012">Publisher</a>.</p>https://spakowiczlab.github.io/updates/grant-a4239ebf0925/Fri, 01 Mar 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-a4239ebf0925/<p><strong>Research Scholar (RSG-23-1023205) (PI: Spakowicz)</strong> begins today.</p> <p>American Cancer Society</p> <p>Lifestyle-based microbiome modification in older adults to promote response to immunotherapy</p> <p>Goal: To understand the causal mechanisms by which the exercise-modified microbiome affects the response to cancer treatment with immune checkpoint inhibitors.</p>https://spakowiczlab.github.io/updates/paper-38259095/Mon, 05 Feb 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-38259095/<p><strong>A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset</strong> was published today in <em>Cancer research communications</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38259095/">Read the paper</a> · <a href="https://doi.org/10.1158/2767-9764.CRC-23-0213">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-38088183/Mon, 05 Feb 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-38088183/<p><strong>The microbiome and gynecologic cancer: cellular mechanisms and clinical applications</strong> was published today in <em>International journal of gynecological cancer : official journal of the International Gynecological Cancer Society</em>.</p>https://spakowiczlab.github.io/updates/preprint-848969b5dd2c/Thu, 01 Feb 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/preprint-848969b5dd2c/<p>Our preprint <strong>Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2024.02.01.577565">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-34044cbc7c6f/Mon, 01 Jan 2024 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-34044cbc7c6f/<p><strong>SIGMA Nursing Research Grant (PI: Han)</strong> begins today.</p> <p>Oncology Nursing Foundation</p> <p>Social determinants of health and race effects on the microbiome and gastro-intestinal toxicity in colorectal cancer</p> <p>Goal: Investigate the use of gut microbiome-immune interactions to prevent and manage GI symptom toxicity for 5-fluoro-uracil-based chemotherapy in colon cancer patients.</p>https://spakowiczlab.github.io/updates/paper-38201238/Fri, 22 Dec 2023 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-38201238/<p><strong>Emerging Immunotherapy Approaches for Advanced Clear Cell Renal Cell Carcinoma</strong> was published today in <em>Cells</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38201238/">Read the paper</a> · <a href="https://doi.org/10.3390/cells13010034">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-38123141/Wed, 20 Dec 2023 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-38123141/<p><strong>Gut Microbiota Richness and Diversity Track With T Cell Aging in Healthy Adults</strong> was published today in <em>The journals of gerontology. Series A, Biological sciences and medical sciences</em>.</p>https://spakowiczlab.github.io/updates/paper-37850841/Tue, 21 Nov 2023 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-37850841/<p><strong>Exogenous Sequences in Tumors and Immune Cells (Exotic): A Tool for Estimating the Microbe Abundances in Tumor RNA-seq Data</strong> was published today in <em>Cancer research communications</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37850841/">Read the paper</a> · <a href="https://doi.org/10.1158/2767-9764.CRC-22-0435">Publisher</a>.</p>https://spakowiczlab.github.io/updates/paper-37897643/Sat, 28 Oct 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-37897643/<p><strong>Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses</strong> was published today in <em>Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation</em>.</p>https://spakowiczlab.github.io/updates/paper-37741201/Thu, 21 Sep 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-37741201/<p><strong>The impact of antibiotic and proton pump inhibitor use at the time of adjuvant platinum-based chemotherapy on survival in patients with endometrial cancer</strong> was published today in <em>Gynecologic oncology</em>.</p>https://spakowiczlab.github.io/updates/grant-6c35f515eb39/Thu, 14 Sep 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-6c35f515eb39/<p><strong>U54CA287392 (PI: Wagener)</strong> begins today.</p> <p>National Cancer Institute</p> <p>The Ohio State University tobacco center of regulatory science (OSU-TCORS)</p> <p>Goal: This project aims to support FDA regulation of new nicotine-containing products by contributing to the understanding of their health and behavioral effects. Dr. Spakowicz will support a project exploring the effect of new nicotine products on the oral microbiome and host markers of inflammation.</p>https://spakowiczlab.github.io/updates/preprint-e1ca3165f89d/Wed, 06 Sep 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-e1ca3165f89d/<p>Our preprint <strong>The tumor microbiome reacts to hypoxia and can influence response to radiation treatment in colorectal cancer</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2023.09.01.555936">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-37628651/Tue, 08 Aug 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-37628651/<p><strong>Deciphering the Tumor-Immune-Microbe Interactions in HPV-Negative Head and Neck Cancer</strong> was published today in <em>Genes</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37628651/">Read the paper</a> · <a href="https://doi.org/10.3390/genes14081599">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/grant-dbd57429bbba/Sat, 01 Jul 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-dbd57429bbba/<p><strong>Innovator Award (104661) (PI: Spakowicz)</strong> begins today.</p> <p>American Lung Association</p> <p>Adenosine as a mediator of tumor and tumor-microbe interactions in non-small cell lung cancer</p> <p>Goal: To understand how microbial purine excretion in the gut and tumor affects immunotherapy treatment outcomes.</p>https://spakowiczlab.github.io/updates/paper-37446025/Thu, 29 Jun 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-37446025/<p><strong>Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers</strong> was published today in <em>International journal of molecular sciences</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37446025/">Read the paper</a> · <a href="https://doi.org/10.3390/ijms241310847">Publisher</a>.</p>https://spakowiczlab.github.io/updates/preprint-b55514db40f7/Thu, 25 May 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-b55514db40f7/<p>Our preprint <strong>The tumor microbiome as a predictor of outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2023.05.24.542123">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/preprint-9679f74573d0/Wed, 24 May 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-9679f74573d0/<p>Our preprint <strong>A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2023.05.24.541982">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/preprint-5c76db4650c3/Tue, 23 May 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-5c76db4650c3/<p>Our preprint <strong>Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers</strong> was posted today.</p> <p><a href="https://doi.org/10.20944/preprints202305.1657.v1">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/paper-37195421/Wed, 17 May 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-37195421/<p><strong>Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression</strong> was published today in <em>Journal of the National Cancer Institute</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37195421/">Read the paper</a> · <a href="https://doi.org/10.1093/jnci/djad091">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-37085156/Fri, 21 Apr 2023 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-37085156/<p><strong>Risk Factors for Immune Checkpoint Inhibitor Immunotherapy Toxicity Among Older Adults with Cancer</strong> was published today in <em>The oncologist</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37085156/">Read the paper</a> · <a href="https://doi.org/10.1093/oncolo/oyad097">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-36795122/Thu, 16 Feb 2023 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-36795122/<p><strong>Mean platelet volume, thrombocytosis, and survival in non-small cell lung cancer patients treated with first-line pembrolizumab alone or with chemotherapy</strong> was published today in <em>Cancer immunology, immunotherapy : CII</em>.</p>https://spakowiczlab.github.io/updates/paper-36738310/Sat, 04 Feb 2023 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-36738310/<p><strong>Association of medical comorbidities and cardiovascular disease with toxicity and survival among patients receiving checkpoint inhibitor immunotherapy</strong> was published today in <em>Cancer immunology, immunotherapy : CII</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36738310/">Read the paper</a> · <a href="https://doi.org/10.1007/s00262-023-03371-0">Publisher</a>.</p>https://spakowiczlab.github.io/updates/grant-37e8d4c65716/Wed, 01 Feb 2023 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-37e8d4c65716/<p><strong>Early Career Investigator Grant</strong> begins today.</p> <p>Ovarian Cancer Research Alliance</p> <p>The Impact of Gut Microbiome and Probiotics on Chemotherapy Response in Ovarian Cancer Patients</p> <p>Goal: To use the prospective collection of gut microbiome samples in a patient cohort and pre-clinical models to assess the microbes associated with chemotherapy response and resistance in ovarian cancer and how outcomes may be altered with probiotics.</p>https://spakowiczlab.github.io/updates/grant-9ddc2c01cc03/Sun, 01 Jan 2023 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-9ddc2c01cc03/<p><strong>National Comprehensive Cancer Center Network/AstraZeneca (PI: Alamadi)</strong> begins today.</p> <p>Improving the Quality of Care and Application of Best Practices in the Treatment of Patients with Small Cell Lung Cancer</p>https://spakowiczlab.github.io/updates/paper-36555172/Thu, 08 Dec 2022 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-36555172/<p><strong>Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers</strong> was published today in <em>International journal of molecular sciences</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36555172/">Read the paper</a> · <a href="https://doi.org/10.3390/ijms232415531">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-36338834/Thu, 20 Oct 2022 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-36338834/<p><strong>Exploratory studies of oral and fecal microbiome in healthy human aging</strong> was published today in <em>Frontiers in aging</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36338834/">Read the paper</a> · <a href="https://doi.org/10.3389/fragi.2022.1002405">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/grant-27fed569fb81/Sat, 01 Oct 2022 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-27fed569fb81/<p><strong>Oncology Nursing Science Grant (PI: Arthur)</strong> begins today.</p> <p>The Oncology Nursing Foundation</p> <p>The Vaginal Microbiome as a Biomarker of Vaginal Health in Women with Breast Cancer</p> <p>Goal: To collect longitudinal vaginal microbiome samples in women receiving hormone therapy for breast cancer and evaluate the extent to which the microbiome can be used to predict treatment outcomes.</p>https://spakowiczlab.github.io/updates/paper-36070148/Wed, 07 Sep 2022 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-36070148/<p><strong>Immune checkpoint inhibitor-induced hepatitis injury: risk factors, outcomes, and impact on survival</strong> was published today in <em>Journal of cancer research and clinical oncology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36070148/">Read the paper</a> · <a href="https://doi.org/10.1007/s00432-022-04340-3">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-a84fedde6a44/Wed, 17 Aug 2022 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-a84fedde6a44/<p>Our preprint <strong>Exogenous sequences in tumors and immune cells (exotic): a tool for estimating the microbe abundances in tumor RNAseq data</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2022.08.16.503205">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-647cb7a98cd4/Fri, 01 Jul 2022 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-647cb7a98cd4/<p><strong>Discovery Catalyst Award (PI: Bittoni)</strong> begins today.</p> <p>American Lung Association</p> <p>BEFIT: An exercise intervention study in a cohort at high risk for developing lung cancer</p> <p>Goal: To assess the feasibility of an exercise intervention in a high-risk cohort and estimate the effect on blood markers of inflammation and the microbiome.</p>https://spakowiczlab.github.io/updates/grant-321de6db0962/Fri, 01 Jul 2022 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-321de6db0962/<p><strong>Sarcoma Foundation of America Research Award (PIs: Spakowicz, Tinoco)</strong> begins today.</p> <p>Sarcoma Foundation of America</p> <p>The sarcoma tumor microbiome as a therapeutic target</p> <p>Goal: to survey the tumor microbiome in sarcoma and explore its use as a clinical biomarker of treatment response for immunotherapy.</p>https://spakowiczlab.github.io/updates/paper-35433441/Thu, 31 Mar 2022 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-35433441/<p><strong>A Geriatric Assessment Intervention to Reduce Treatment Toxicity Among Older Adults With Advanced Lung Cancer: A Subgroup Analysis From a Cluster Randomized Controlled Trial</strong> was published today in <em>Frontiers in oncology</em>.</p>https://spakowiczlab.github.io/updates/paper-35131184/Sat, 08 Jan 2022 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-35131184/<p><strong>Serum Albumin: Early Prognostic Marker of Benefit for Immune Checkpoint Inhibitor Monotherapy But Not Chemoimmunotherapy</strong> was published today in <em>Clinical lung cancer</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/35131184/">Read the paper</a> · <a href="https://doi.org/10.1016/j.cllc.2021.12.010">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/grant-d3de52cee38d/Sat, 01 Jan 2022 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-d3de52cee38d/<p><strong>Pelotonia Population Health Award (PIs: Spakowicz, Zhu)</strong> begins today.</p> <p>Pelotonia Non-profit Research Foundation</p> <p>Dietary interventions to modify the response to immunotherapy: a companion assessment within the NutriCare Study</p>https://spakowiczlab.github.io/updates/paper-34424894/Mon, 23 Aug 2021 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-34424894/<p><strong>Bayesian structural time series for biomedical sensor data: A flexible modeling framework for evaluating interventions</strong> was published today in <em>PLoS computational biology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34424894/">Read the paper</a> · <a href="https://doi.org/10.1371/journal.pcbi.1009303">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-a8a2ea10ccc3/Fri, 30 Jul 2021 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-a8a2ea10ccc3/<p>Our preprint <strong>Early changes in lymphocyte/monocyte ratio on-treatment as a prognostic marker to predict overall survival in patients with advanced cancer treated with immune checkpoint inhibitors</strong> was posted today.</p>https://spakowiczlab.github.io/updates/grant-7163f76eb7ac/Thu, 01 Jul 2021 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-7163f76eb7ac/<p><strong>K01AG070310 Mentored Career Development Award (PI: Spakowicz)</strong> begins today.</p> <p>NIH-National Institutes on Aging</p> <p>The microbiome in older adults with lung cancer association of treatment regimens and diet with protective microbial profiles</p>https://spakowiczlab.github.io/updates/grant-157f8866e527/Thu, 01 Jul 2021 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-157f8866e527/<p><strong>OSU Department of Internal Medicine Seed Grant (PI: Malalur, Spakowicz)</strong> begins today.</p> <p>Circulating microbial DNA as a non-invasive biomarker for colorectal cancer</p> <p>Goal: To develop methods for non-invasive prediction of cancer, treatment or outcomes using blood-based analysis of microbial DNA.</p>https://spakowiczlab.github.io/updates/paper-33878726/Tue, 20 Apr 2021 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-33878726/<p><strong>Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors</strong> was published today in <em>Journal of the National Comprehensive Cancer Network : JNCCN</em>.</p>https://spakowiczlab.github.io/updates/paper-33627226/Sun, 21 Feb 2021 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-33627226/<p><strong>Checkpoint inhibitor immunotherapy toxicity and overall survival among older adults with advanced cancer</strong> was published today in <em>Journal of geriatric oncology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33627226/">Read the paper</a> · <a href="https://doi.org/10.1016/j.jgo.2021.02.002">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-33612452/Thu, 18 Feb 2021 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-33612452/<p><strong>The aging microbiome and response to immunotherapy: Considerations for the treatment of older adults with cancer</strong> was published today in <em>Journal of geriatric oncology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33612452/">Read the paper</a> · <a href="https://doi.org/10.1016/j.jgo.2021.02.001">Publisher</a>.</p>https://spakowiczlab.github.io/updates/grant-24f71201dcb2/Mon, 01 Feb 2021 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-24f71201dcb2/<p><strong>1R01CA248741-01A1 (PI: Carbone, Dikov)</strong> begins today.</p> <p>NIH-NCI</p> <p>Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer</p> <p>Goal: To evaluate (1) the safety and tolerability of combination PBF-1129 with nivolumab, (2) the correlation between immunological parameters and adenosine generation, the microbiome and signaling, and (3) the efficacy of PBF-1129 in targeting adenosine-mediated immunosuppression.</p>https://spakowiczlab.github.io/updates/grant-a9a46b975473/Fri, 01 Jan 2021 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-a9a46b975473/<p><strong>Pelotonia Clinical Trial Award (PI: Spakowicz, Arthur)</strong> begins today.</p> <p>Pelotonia Non-profit Research Foundation</p> <p>The vaginal microbiome as a biomarker of pelvic health and patient-reported outcomes in women receiving pelvic radiation.</p>https://spakowiczlab.github.io/updates/grant-a6ed7cd8d5f0/Sun, 01 Nov 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-a6ed7cd8d5f0/<p><strong>2020 Intramural Supportive Care Pilot Research Award (PI: Spakowicz, Arthur)</strong> begins today.</p> <p>OSU Comprehensive Cancer Center Intramural Research Program</p> <p>Preliminary studies of the vaginal microbiome as a biomarker of pelvic health and patient-reported outcomes in women receiving pelvic radiation.</p>https://spakowiczlab.github.io/updates/paper-33059594/Thu, 15 Oct 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-33059594/<p><strong>Latent-space embedding of expression data identifies gene signatures from sputum samples of asthmatic patients</strong> was published today in <em>BMC bioinformatics</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33059594/">Read the paper</a> · <a href="https://doi.org/10.1186/s12859-020-03785-y">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/pelotonia-black-raspberry-juice/Wed, 14 Oct 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/pelotonia-black-raspberry-juice/<p><a href="https://youtu.be/6kETfllNeJw">Watch the video</a>.</p>https://spakowiczlab.github.io/updates/james-cancer-free-world-podcast/Tue, 13 Oct 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/james-cancer-free-world-podcast/<p>Dan discusses how the microbiome impacts cancer treatment on The James Cancer-Free World Podcast.</p> <p><a href="https://soundcloud.com/thejamescancerfreeworld/james-spakowicz">Listen to Episode 76</a>.</p>https://spakowiczlab.github.io/updates/paper-32854644/Thu, 27 Aug 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-32854644/<p><strong>Post-diagnosis dietary insulinemic potential and survival outcomes among colorectal cancer patients</strong> was published today in <em>BMC cancer</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32854644/">Read the paper</a> · <a href="https://doi.org/10.1186/s12885-020-07288-0">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/channel-10-towards-a-cancer-free-world/Thu, 13 Aug 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/channel-10-towards-a-cancer-free-world/<p>Raspberries could be a key to lung cancer prevention, Ohio State research shows.</p> <p><a href="https://www.youtube.com/watch?v=9gTsZewaMWQ&amp;t=11s">Watch the Channel 10 video</a>.</p>https://spakowiczlab.github.io/updates/grant-dce896ab0279/Sat, 01 Aug 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-dce896ab0279/<p><strong>Pilot Grant Award (PI: Mo)</strong> begins today.</p> <p>OSU Department of Biomedical Informatics</p> <p>The Epigenetic Landscape and Correlation with Microbiome in the Early Onset Colorectal Cancer</p> <p>Goal: To explore associations between intra-tumor microbes and epigenetic modifications with early onset colorectal cancer using publicly available and the oncology research information exchange network data.</p>https://spakowiczlab.github.io/updates/paper-32728772/Wed, 29 Jul 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-32728772/<p><strong>Brief report: inhaled corticosteroid use and the risk of checkpoint inhibitor pneumonitis in patients with advanced cancer</strong> was published today in <em>Cancer immunology, immunotherapy : CII</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32728772/">Read the paper</a> · <a href="https://doi.org/10.1007/s00262-020-02674-w">Publisher</a>.</p>https://spakowiczlab.github.io/updates/office-of-research-twitter/Tue, 21 Jul 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/office-of-research-twitter/<p>Dr. Spakowicz of The Ohio State University is now on <a href="https://twitter.com/dspakowicz">Twitter</a>.</p> <p><a href="https://twitter.com/researchatOSU/status/1285550098873749510">See the Office of Research announcement</a>.</p>https://spakowiczlab.github.io/updates/channel-12-berry-juice/Mon, 20 Jul 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/channel-12-berry-juice/<p>Interview with Dr. Spakowicz on how berry juice may help lung cancer patients!</p> <p><a href="https://local12.com/health/the-james-at-ohio-state/berry-juice-may-help-lung-cancer-patients-ohio-state-university-comprehensive-cancer-center-arthur-g-james-cancer-hospital-and-richard-j-solove-research-institute-columbus-cincinnati"><img src="https://spakowiczlab.github.io/files/2020/08/Berry-Video.png" alt="Channel 12 interview about berry juice and lung cancer."></a></p>https://spakowiczlab.github.io/updates/grant-513bb0c93112/Wed, 01 Jul 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-513bb0c93112/<p><strong>Nye-Rayden Cancer Research Award (PI: Spakowicz)</strong> begins today.</p> <p>OSU Division of Medical Oncology</p> <p>Increasing response to immunotherapy through diet-based alterations of the microbiome: a mouse validation study</p> <p>Goal: This proposal will bridge the ongoing BE WELL trial to cancer ICI response in preclinical models. Specifically, we will determine whether the microbiome shifts elicited by BRB in the clinical study affect response ICIs in a mouse model of lung cancer. We will also use metagenomics and metabolomics to evaluate the mechanism by which the foods lead to microbial community changes.</p>https://spakowiczlab.github.io/updates/grant-5c2735b92003/Wed, 01 Jul 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-5c2735b92003/<p><strong>Research Award Seed Grant (PI: Jin, Spakowicz)</strong> begins today.</p> <p>OSU Division of Medical Oncology</p> <p>The Epigenetic Landscape and Correlation with Microbiome in the Early Onset Colorectal Cancer</p> <p>Goal: To observe the correlations between the tumor microbiome and methylation in colorectal cancer as a potential mechanism for the rise in early onset colorectal cancer.</p>https://spakowiczlab.github.io/updates/paper-32571363/Mon, 22 Jun 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-32571363/<p><strong>Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients</strong> was published today in <em>Genome biology</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32571363/">Read the paper</a> · <a href="https://doi.org/10.1186/s13059-020-02033-z">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-32407116/Thu, 14 May 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-32407116/<p><strong>A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma</strong> was published today in <em>Journal of natural products</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32407116/">Read the paper</a> · <a href="https://doi.org/10.1021/acs.jnatprod.0c00012">Publisher</a>.</p>https://spakowiczlab.github.io/updates/paper-32375706/Wed, 06 May 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-32375706/<p><strong>Inferring the role of the microbiome on survival in patients treated with immune checkpoint inhibitors: causal modeling, timing, and classes of concomitant medications</strong> was published today in <em>BMC cancer</em>.</p>https://spakowiczlab.github.io/updates/paper-32366680/Mon, 04 May 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-32366680/<p><strong>Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With Clostridia and Insulin Sensitivity in Humans</strong> was published today in <em>Diabetes</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32366680/">Read the paper</a> · <a href="https://doi.org/10.2337/db19-0592">Publisher</a>.</p>https://spakowiczlab.github.io/updates/pelotonia-funding-video/Mon, 30 Mar 2020 00:00:00 -0400https://spakowiczlab.github.io/updates/pelotonia-funding-video/<p>Dr. Spakowicz discusses the effects of the gut microbiome in cancer patients.</p> <p><a href="https://u.osu.edu/spakowiczlab/files/2020/03/2019-Pelotonia-Idea-Grants-Daniel-J.-Spakowicz-PhD.mp4">Watch the video</a>.</p>https://spakowiczlab.github.io/updates/preprint-466c51d50c42/Wed, 04 Mar 2020 00:00:00 -0500https://spakowiczlab.github.io/updates/preprint-466c51d50c42/<p>Our preprint <strong>Bayesian Structural Time Series for Biomedical Sensor Data: A Flexible Modeling Framework for Evaluating Interventions</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/2020.03.02.973677">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-9aea22bd35fb/Wed, 01 Jan 2020 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-9aea22bd35fb/<p><strong>Young Investigator Research Award in Immuno-oncology (PI: Spakowicz)</strong> begins today.</p> <p>LCFA-BMS/ILC Foundation</p> <p>Evaluating modifiable biomarkers for the prediction of immunotherapy response and toxicity</p> <p>Goal: This award is to evaluate the predictive strength of the microbiome and physical activity for cancer treatment responses, relative and in addition to tumor biomarkers such as PD1/PDL1 and tumor mutational burden. The hope is that, because these biomarkers can be modified, we will estimate to what extent the response to treatment can be altered by controlling these two variables.</p>https://spakowiczlab.github.io/updates/grant-9c3831778fa9/Sat, 14 Dec 2019 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-9c3831778fa9/<p><strong>Secondary Analysis of Existing Datasets (PI: Spakowicz, Mo)</strong> begins today.</p> <p>2019 CCTS Pilot Translational &amp; Clinical Studies Program</p> <p>Exogenous sequences in unmapped transcriptome data from the ORIEN consortium</p>https://spakowiczlab.github.io/updates/paper-31695033/Wed, 06 Nov 2019 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-31695033/<p><strong>Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis</strong> was published today in <em>Nature communications</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31695033/">Read the paper</a> · <a href="https://doi.org/10.1038/s41467-019-13036-1">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/recent-work-on-twitter/Thu, 03 Oct 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/recent-work-on-twitter/<p><a href="https://twitter.com/dspakowicz/status/1179864781513035776">See the lab’s recent work on Dr. Spakowicz’s Twitter</a>.</p>https://spakowiczlab.github.io/updates/preprint-db819a6edd44/Fri, 13 Sep 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-db819a6edd44/<p>Our preprint <strong>Inferring the role of the microbiome on survival in patients treated with immune checkpoint inhibitors: causal modeling, timing, and classes of concomitant medications</strong> was posted today.</p>https://spakowiczlab.github.io/updates/preprint-01a8d270b9c1/Wed, 11 Sep 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-01a8d270b9c1/<p>Our preprint <strong>Approaches for integrating heterogeneous RNA-seq data reveals cross-talk between microbes and genes in asthmatic patients</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/765297">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/grant-e60c1f4536c6/Sun, 01 Sep 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-e60c1f4536c6/<p><strong>Foods for Health (FFH) Discovery Theme Seed Grants (PI: Zhu, Spakowicz, Ma)</strong> begins today.</p> <p>Internal OSU</p> <p>Food Products for the Targeted Enrichment of Gut Microbes</p> <p>Goal: With this award we will set up a model gut system to rapidly assess the effects of food molecules on microbial communities in vitro. In addition, we will develop a model for predicting the response to inputs by combining two tools created by OSU faculty, Spakowicz and Ma.</p>https://spakowiczlab.github.io/updates/paper-31367835/Wed, 31 Jul 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-31367835/<p><strong>Change in neutrophil to lymphocyte ratio during immunotherapy treatment is a non-linear predictor of patient outcomes in advanced cancers</strong> was published today in <em>Journal of cancer research and clinical oncology</em>.</p>https://spakowiczlab.github.io/updates/grant-355087c7898b/Tue, 02 Jul 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-355087c7898b/<p><strong>2K12CA133250-06A1 (PI: Byrd, Awardee: Presley)</strong> begins today.</p> <p>NCI</p> <p>OSU K12 Training Grant For Clinical Faculty Investigators</p> <p>Goal: The goal of this proposal is to mentor and effectively train faculty-level investigators in basic science and/or clinically oriented approaches to translational research.</p>https://spakowiczlab.github.io/updates/paper-31142858/Wed, 29 May 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/paper-31142858/<p><strong>Longitudinal multi-omics of host-microbe dynamics in prediabetes</strong> was published today in <em>Nature</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31142858/">Read the paper</a> · <a href="https://doi.org/10.1038/s41586-019-1236-x">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/preprint-a2e8f5df5a66/Wed, 22 May 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/preprint-a2e8f5df5a66/<p>Our preprint <strong>Latent-space embedding of expression data identifies gene signatures from sputum samples of asthmatic patients</strong> was posted today.</p> <p><a href="https://doi.org/10.1101/646976">Read the preprint</a>. This is a preprint and has not yet been peer reviewed.</p>https://spakowiczlab.github.io/updates/pelotonia-facebook-live/Thu, 25 Apr 2019 00:00:00 -0400https://spakowiczlab.github.io/updates/pelotonia-facebook-live/<p>Dan was interviewed on Facebook Live.</p> <p><a href="https://u.osu.edu/spakowiczlab/files/2019/10/Facebook-Video.mp4">Watch the Pelotonia video</a>.</p>https://spakowiczlab.github.io/updates/grant-eb95990cce88/Tue, 01 Jan 2019 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-eb95990cce88/<p><strong>OSU Hematology Department Research Funds (PI: Choe, Spakowicz)</strong> begins today.</p> <p>Longitudinal analysis of the impact of Vitamin A on stool microbiota post-hematopoietic stem cell transplantation (HSCT).</p> <p>Goal: This award seeks to modify the microbiome by decreasing gut tight junction leakiness, thereby reducing bloodstream infections and graft versus host disease.</p>https://spakowiczlab.github.io/updates/grant-80937d265f2a/Tue, 01 Jan 2019 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-80937d265f2a/<p><strong>Pelotonia Clinical Trial Award (PIs: Spakowicz, Carbone, Clinton)</strong> begins today.</p> <p>Pelotonia Non-profit Research Foundation</p> <p>Pilot study to define compliance and impact of a novel black raspberry food product on the microbiome and immune functions in a high-risk cohort for lung cancer.</p>https://spakowiczlab.github.io/updates/grant-de2d0f3db4a2/Tue, 01 Jan 2019 00:00:00 -0500https://spakowiczlab.github.io/updates/grant-de2d0f3db4a2/<p><strong>Pelotonia New Investigator Award (PI: Spakowicz)</strong> begins today.</p> <p>Pelotonia Non-profit Research Foundation</p> <p>The Effect of the Microbiome on Immune Checkpoint Inhibitor Response and Corticosteroid Use in Melanoma</p> <p>Goal: This award will study the how the microbiome interacts with the immune system in the context of immunotherapy for melanoma with specific focus on toxicity and corticosteroid use. All microbiome processing, data generation, analysis and integration will be performed in my lab.</p>https://spakowiczlab.github.io/updates/grant-c93650227a8b/Sun, 01 Jul 2018 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-c93650227a8b/<p><strong>Davis Bremmer Award (PI: Presley)</strong> begins today.</p> <p>OSU Center for Clinical &amp; Translational Science (CCTS)</p> <p>The Aging Immune System, Treatment Response, and Functional Decline among Older Adults with Lung Cancer</p>https://spakowiczlab.github.io/updates/grant-48cbede5b84f/Sun, 01 Jul 2018 00:00:00 -0400https://spakowiczlab.github.io/updates/grant-48cbede5b84f/<p><strong>Pelotonia New Investigator Award (PI: Presley)</strong> begins today.</p> <p>Pelotonia Non-profit Research Foundation</p> <p>The Aging Immune System, Treatment Response, and Functional Decline among Older Adults with Lung Cancer</p> <p>Goal: This award will study how the microbiome interacts with the aging immune system in the context of lung cancer therapy. All microbiome processing, data generation, analysis, and integration will be performed in my lab.</p>https://spakowiczlab.github.io/updates/paper-29361466/Wed, 17 Jan 2018 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-29361466/<p><strong>Integrative Personal Omics Profiles during Periods of Weight Gain and Loss</strong> was published today in <em>Cell systems</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29361466/">Read the paper</a> · <a href="https://doi.org/10.1016/j.cels.2017.12.013">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>https://spakowiczlab.github.io/updates/paper-29184560/Tue, 14 Nov 2017 00:00:00 -0500https://spakowiczlab.github.io/updates/paper-29184560/<p><strong>Volatile Metabolomic Composition of Vitex Species: Chemodiversity Insights and Acaricidal Activity</strong> was published today in <em>Frontiers in plant science</em>.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29184560/">Read the paper</a> · <a href="https://doi.org/10.3389/fpls.2017.01931">Publisher</a>.</p> <p><a href="https://spakowiczlab.github.io/publications/">Browse all publications</a>.</p>